Welcome to the Yip lab at the University of Toronto
Our research focus is in single molecule biophysics. We are interested in understanding the fundamental mechanisms associated with how molecules assemble to form supramolecular architectures. This can range from small molecule systems through peptides to proteins. We have a particular interest in assembly at interfaces and surfaces, including cell membranes. Our research team comprises engineers, chemists, physicists, biologists, and life scientists and we bring a trans-, cross-, and multidisciplinary approach to our studies.
Our research program focuses on phenomena that take place on molecular length scales. We are particularly interested in understanding the structural, chemical, and physical interactions that drive the interactions between molecules. Such insights are critical for fields as diverse as biology, nanotechnology, and engineering. To accomplish this, we are applying a multifacted approach, which combines the design and implementation of novel functional imaging and characterization tools for studying phenomena in the single molecule scale, with computational techniques. Research in our group spans the gamut from studies of how proteins and peptides interact with cellular membranes, which has importance for understanding how toxins work, to tracking of molecular dynamics in live cells, to mapping of the nanoscale physical, chemical, and electronic properties of soft materials.
Our research projects have been supported by NSERC, CIHR, the Canada Foundation for Innovation, and the Canada Research Chairs program. We are grateful for the support of Eli Lilly and Company, Eli Lilly Canada, Olympus Canada, Veeco, and Systems for Research